Question 1

what is a prothrombin gene mutation? it is something worth worrying about whether you have it or not?

Accepted Answer

PGM: Prothrombin gene mutation is an inherited coagulopathy. This means that if you have this gene mutation, you can be at increased risk of forming clots in certain veins in your body. These clots can be dangerous and even lead to death. We do not routinely check for this mutation but do order this test if a young patient develops a deep blood clot.

Question 2

i have prothrombin gene mutation g20210a, i'm pretty sure i follow under a vitamin defect. is their anything i can do?

Accepted Answer

Prothrombin G20210A: Prothrombin is the precursor of thrombin in the coagulation pathway; it is synthesized in the liver, much as other vitamin k – dependent proteins are.The prothrombin gene is found at 11p11-q12) on chromosome 11.[3] mutation at position 20210 of the gene results in thrombophilia.This coagulopathy is more likely to cause venous thrombosis rather than arterial disease. Is not related to a vitamin deficit. Coumadin (warfarin) is the treatment of choice. You seem to be in the hands of a good hematologist. I am truly sorry to hear about your stroke.I can understand your concerns as i also suffer from three clotting factor disorders and am on coumadin (warfarin). Best wishes for a happy and healthy new year.

Question 3

i have prothrombin gene mutation g20210a,  i've had a p.e & dvt & stroke in the past 2 years. cancer runs in the family, but i'm currently cancer free?

Accepted Answer

What's your question: We'd all like to help, but you haven't made clear what you're asking. I'm glad you're being treated after your thrombotic events. If you can let us know exactly what we can do for you, please resend your question.

Question 4

painful lump on back of knee. small bruise thats got bigger and darker over the days. i have prothrombin gene mutation. not in any pain. ?

Accepted Answer

Exam needed: This may be a Baker's cyst that ruptured. Superficial phlebitis is another possibility. Your physician or an orthopedic surgeon should examine this lump for diagnosis and treatment advice. An ultrasound may be ordered.

Question 5

is cancer my next battle? after stroke,  dvt, p.e. i have prothrombin gene mutation g20210a. i'm currently cancer free but what are my odds?

Accepted Answer

Why do you ask?: You have given me no reason to believe that you have cancer. The cancer that's most famous for causing thrombi -- common pancreatic cancer -- would be very rare at you age of 29. I suspect you have some additional unknown cause of hypercoagulable blood and need to stay under the care of a good hematologist. If you do develop a mass or new symptoms, get seen, but don't let fear ruin your life now.

Question 6

gene mutations and pregnancy, can you tell me more about this?

Accepted Answer

Pregnancy mutations: Conception is a function of two sets of chromosomes, 22 + X from an egg and 22 + X or Y from a sperm. The resultant combination goes through a "re-mixing"_ process that requires pairing the chromosomes with subsequent "detachment" If the detachment process is not a complete "pair", then gene mutations occur especially in women older than age 37.

Question 7

can prothrombin genetic mutation be inherited?

Accepted Answer

Yes: Genetic mutations are by definition inherited.

Question 8

if a woman takes a high risk medication during pregnancy, is it possible for the med to cause some type of mutation of genes resulting in birth defects?

Accepted Answer

: Thalidomide is a nausea med available in Britain &amp; less so in Canada about 60 yrs ago. Women who took it between 5-8 wks of pregnancy often gave birth to babies with deformed or absent arms or legs. Later research led to classification of drugs by  the risks they posed during pregnancy. Genes are firmly in place by the time of conception, but drugs effect can alter how those genes work.

Question 9

does heterozygous for mthfr gene mutation affect pregnancy?, and what about taking synthetic folic acid supplement?

Accepted Answer

Controversial...: Some studies have shown an association between the  MTHFR gene mutation and recurrent miscarriages but this is controversial.  Aside from this possibility, it doesn't cause problems with pregnancy.  If you have this mutation, its a good idea to take folic acid, vitamin B-12 and Vitamen B-6.  Aspirin is also sometimes recommended for women for who have had recurrent miscarriages.  Best wishes!

Question 10

do all mthfr gene mutations benefit from folate over folic acid? or certain stands?   is there different treatment for heterozygous v homozygous?

Accepted Answer

Need activated folat: You need to take methyl tetrahydrofolate (folic acid) to bypass your genetic abnormality or take massive doses of folate (folic acid)--such as 3 grams. You can determine what is adequate by measuring your homocysteine level.
Folic acid and folate (folic acid) are the same thing. You may be thinking about folinic acid., .

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Doctor answers about:

Treatment of prothrombin factor 2 gene mutation during pregnancy

A member asked:

What is a prothrombin gene mutation? it is something worth worrying about whether you have it or not?

A member asked:

I have prothrombin gene mutation g20210a, i'm pretty sure i follow under a vitamin defect. is their anything i can do?

A member asked:

I have prothrombin gene mutation g20210a, i've had a p.e & dvt & stroke in the past 2 years. cancer runs in the family, but i'm currently cancer free?

A member asked:

Painful lump on back of knee. small bruise thats got bigger and darker over the days. i have prothrombin gene mutation. not in any pain. ?

A member asked:

Is cancer my next battle? after stroke, dvt, p.e. i have prothrombin gene mutation g20210a. i'm currently cancer free but what are my odds?

A member asked:

Gene mutations and pregnancy, can you tell me more about this?

A member asked:

Can prothrombin genetic mutation be inherited?

A member asked:

If a woman takes a high risk medication during pregnancy, is it possible for the med to cause some type of mutation of genes resulting in birth defects?

A member asked:

Does heterozygous for mthfr gene mutation affect pregnancy?, and what about taking synthetic folic acid supplement?

A member asked:

Do all mthfr gene mutations benefit from folate over folic acid? or certain stands? is there different treatment for heterozygous v homozygous?

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