Question 1

what is myeloma?

Accepted Answer

Bone marrow disease: Myeloma is a malignant disorder characterized by excessive growth of plasma cells. It can several complications: excess levels of calcium in the blood, kidney failure, nerve damage, weakening of the bones, increased risk of infections (to name a few).

Question 2

all info about myeloma?

Accepted Answer

Myeloma Foundation: Check out the international myeloma foundation web site: http://myeloma.Org/main.Action" rel="nofollow" target="_blank">http://myeloma.Org/main.Action. Also the myeloma research foundation:

Question 3

how bad is pain in myeloma?

Accepted Answer

Only if fracture +: Not everybody who has myeloma will have fracture when diagnosed. Yes, myeloma will involve the bone and there would be increased risk for fracture- however- just because one has myeloma-it does not mean that it is identical to pain unless you have fracture. And if you do-it depends on your tolerance to pain and how severe the fracture is. Pain is very subjective. Discuss with oncologist.

Question 4

what tests diagnose myeloma?

Accepted Answer

Electrophoresis and: Free serum light chain tests.  Multiple myeloma is generally diagnosed by electrophoresis of serum, urine and free serum light chain test.  X-rays of the bone may reveal lytic lesions that are a strong indicator of the disease.  Confirmation of the diagnosis requires examination of bone marrow by a pathologist.

Question 5

what is nonsecretory myeloma?

Accepted Answer

No M-spike MM: Non-secretory multiple myeloma is myeloma that is diagnosed by the presence of plasma cells in the bone marrow and crab symptoms -- hypercalcemia, renal (kidney) problems, anemia, and bone problems (eg osteoporosis or lytic lesions) without an monoconal (m)-spike on serum protein electrophoresis (spep). A large study by kyle et al. At mayo suggested 7% of mm pts. Likely less now with flc testing.

Question 6

what are the signs of myeloma?

Accepted Answer

Myeloma: Myeloma is cancer of the plasma cells.It is diagnosed through series of blood works, imaging like skeletal bone survey or MRI or pet scan, and a bone marrow biopsy. Signs and symptoms may include anemia ( fatigue, lack of energy etc) , increased serum calcium ( can be presented with confusion, dehydration, increase urination etc), kidney failure (declining renal function), bony pain, fracture, etc.

Question 7

is plasma cell myeloma hereditary?

Accepted Answer

No: It occasionally occurs in families but this is quite rare. This always brings up the question if it is hereditary or more environmentally related.

Question 8

wo is at risk for  multipule myeloma?

Accepted Answer

Unknown/MGUS: The exact cause of multiple myeloma is not known. Myeloma is almost always (?Always) preceded by monoclonal gammopathy of undetermined significance (mgus). Risks: age, male gender, black race; radiation, benzene/petroleum exposure. Laboratory studies can help predict risk of conversion from mgus to myeloma. Genome sequencing may help provide answers in populations and individuals.

Question 9

is there any chemical that  cause myeloma?

Accepted Answer

Not really: There have been associations with certain dyes and herbicides but no strong associations other than exposure to high doses of radiation.

Question 10

what are the different stages is the myeloma?

Accepted Answer

ISS - Greipp et al.: International staging system -- the international staging system (iss) for myeloma was published by the intl myeloma working group in 2005: it is useful for comparing clinical trial , but has limited utility for each individual. Stage i: β2-microglobulin (β2m) < 3.5 mg/l, Albumin >= 3.5 g/dl stage ii: β2m < 3.5 & Albumin < 3.5 ; or β2m 3.5- 5.5 irrespective of serum albumin stage iii: β2m >= 5.5.

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Multile myeloma

A member asked:

What is myeloma?

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All info about myeloma?

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How bad is pain in myeloma?

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What tests diagnose myeloma?

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What is nonsecretory myeloma?

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What are the signs of myeloma?

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Is plasma cell myeloma hereditary?

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Wo is at risk for multipule myeloma?

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Is there any chemical that cause myeloma?

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What are the different stages is the myeloma?

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