Question 1

what r symptoms & best treatment of mast cell disease? i get constant hive reactions to every med i try, freq rashes, wondering if mast is my issue.

Accepted Answer

See allergist: First you need a blood test to confirm whether you have a mast cell disorder to start with.   If the blood test is positive, then one will have to work up the cause for the mast cell disorder.  The usual treatment in high doses of antihistamine but you really need to find out whether your problem is from a mast cell issue or something else. A b/c allergist should be the one you consult.

Question 2

what is mast cell disease and how does it manifest in infants?

Accepted Answer

Brownish lesions on: Mastocytosis is when you have collections of mast cells, usually on the skin.  These are brown spots, (1 or many) if you scratch them they turn red and swollen for a while (they form a wheal as histamine is released)  Usually harmless, but a systemic form exists, not very common, with lesions in bone and other organs.

Question 3

is chronic urticaria a mast cell disease?

Accepted Answer

Urticaria: Urticaria, a clinically distressing disorder, is dermal oedema resulting from vascular dilatation and leakage of fluid into surrounding tissue, often in response to histamine (and other mediators) released from mast cells. A clear history of events surrounding the onset, together with laboratory investigations, in some cases allows us to find a cause and eliminate it.

Question 4

whats chronic urticaria vs mast cell disease?

Accepted Answer

Complex problems: There are at least five important systemic mast cell diseases (mastocytosis) and even more causes of chronic urticaria (of which some mastocytosis diseases are only one cause).  Often, no cause is ever found for chronic urticaria.  A hematologist will probably treat mast cell disease -- perhaps in a research study -- while a dermatologist will manage chronic urticaria.  Good luck; stay proactive.

Question 5

help please.suspect mcad (mast cell disease) - tryptase and mutliple gi confirmations-possible organ damage. any dfw hospitals that will admit / help?

Accepted Answer

See allergist: Your problem can usually be handled by your allergist and there is nothing more that can be done at a hospital unless you have organ failure. You likely need a bone marrow biopsy by a hematologist as well. I also note that you are not taking any antihistamine at all.

Question 6

male 22, doc suspects mast cell disease. i use zantac (ranitidine) for my acid, can i take ceritrizine otc myself until i get tested? is it safe to take both?

Accepted Answer

Mast cell disease: Mast cells disease can cause acid reflux and hives and itching and you can use zantac (ranitidine) and Cetirizine to treat the symptoms. Not sure if your doctor wants to do a skin test, but zyrtec will affect it, so check with your doctor first. If the doctor only wants to do blood tests, you can go ahead and take both, but check with your doctor first.

Question 7

recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. shouldn't biopsy  give more definitive diagnosis?

Accepted Answer

Biopsy: Pathologists describe the type of cells they see and suggest a compatible diagnosis but cannot give a definitive dianosis themselves. You may have urticarial vasculitis. Mastocytosis will need to be ruled out based on the pathology findings too.

Question 8

throat feels very tight. mild swelling of face/hands. hr, sats, bp are fine. possible mast cell disease. can't be anaphylaxis w/ normal vitals, right?

Accepted Answer

Need to be seen: May need some blood work and a detailed history and exam. Allergy season may bring on or trigger such events too.

Question 9

other than antihistamines, and mast cell blockers, what therapies or treatments are available?  pros and cons?  what should i make a point of asking?

Accepted Answer

See an Allergist: You really should not try to seek the "best" treatment based on an internet chat room interview. See an allergist for testing and both of you can come up with the best plan of actions (shots, medications, avoidance) recommended. Why risk hurting yourself or blaming a doctor who is simply trying to help you but is doing so blindly through an internet "help" site.

Question 10

can h pylori cause mast cell activation disease?

Accepted Answer

Unknown: We don't know the causes for MCAS, so yes, it's possible HP is a cause of it.

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Doctor answers about:

Mast cell disease treatment

A member asked:

What r symptoms & best treatment of mast cell disease? i get constant hive reactions to every med i try, freq rashes, wondering if mast is my issue.

A member asked:

What is mast cell disease and how does it manifest in infants?

A member asked:

Is chronic urticaria a mast cell disease?

A member asked:

Whats chronic urticaria vs mast cell disease?

A member asked:

Help please.suspect mcad (mast cell disease) - tryptase and mutliple gi confirmations-possible organ damage. any dfw hospitals that will admit / help?

A member asked:

Male 22, doc suspects mast cell disease. i use zantac (ranitidine) for my acid, can i take ceritrizine otc myself until i get tested? is it safe to take both?

A member asked:

Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. shouldn't biopsy give more definitive diagnosis?

A member asked:

Throat feels very tight. mild swelling of face/hands. hr, sats, bp are fine. possible mast cell disease. can't be anaphylaxis w/ normal vitals, right?

A member asked:

Other than antihistamines, and mast cell blockers, what therapies or treatments are available? pros and cons? what should i make a point of asking?

A member asked:

Can h pylori cause mast cell activation disease?

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