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loratidine and hydroxyzine

A 38-year-old member asked:
Dr. Franklyn Gergits
28 years experience in ENT and Head and Neck Surgery
Hydroxyzine/Claritin: Hello, yes these two antihistamines are commonly used together. I usually use Hydroxyzine at night and Claritin (loratadine) during the day. If excess ... Read More

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A 73-year-old member asked:
Dr. Gregory Hines
23 years experience in Family Medicine
Yes, but...: Given that they are both antihistamines, you may not see much of an effect if they are taken in close time frame. You can take Claritin in the mornin ... Read More
A 52-year-old member asked:
Dr. John Chiu
Dr. John Chiu answered
56 years experience in Allergy and Immunology
Yes: No problem.
A 40-year-old female asked:
Dr. Al Hegab
Dr. Al Hegab answered
39 years experience in Allergy and Immunology
Yes you can: But better hydroxyzine at night and loratadine in the morning. Don't exceed prescribed dosages, and keep the follow up with your doctors. Loratadine s ... Read More
A 39-year-old member asked:
Dr. Michael Zacharisen
32 years experience in Allergy and Immunology
Ok not necessary?: Both Cetirizine (zyrtec) and Diphenhydramine (benadryl) are antihistamines. While there is little harm in taking the 2 together (except drowsiness in ... Read More
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A 52-year-old member asked:
Dr. Thomas Riney
36 years experience in Pediatrics
Duplicative: No need to take benedryl if on zyrtec (cetirizine).
A 42-year-old member asked:
Dr. Roji Andrews
28 years experience in Pediatrics
Not recommended: Both Claritin and Benadryl (diphenhydramine) are anti histamines. Claritin is long acting usually used once a day and Benadryl (diphenhydramine) is sh ... Read More
A 45-year-old member asked:
Dr. John Chiu
Dr. John Chiu answered
56 years experience in Allergy and Immunology
No and yes: They are both antihistamines but Benadryl (diphenhydramine) often causes drowsiness but is more effective in drying up the nose. It also has a shorter ... Read More
A 68-year-old female asked:
Dr. Jack Mutnick
16 years experience in Allergy and Immunology
Yes, with caution: All are h1 antihistamines. Benadryl (diphenhydramine) will cause drowsiness but lasts only 4-6 hours. Zyrtec is a stronger antihistamine than Claritin ... Read More
A 68-year-old female asked:
Dr. Alvin Lin
Dr. Alvin Lin answered
29 years experience in Geriatrics
Don't take together: All 3 drugs mentioned are antihistamines available w/o prescription. Benadryl (diphenhydramine) is most potent but also most laden w/anticholinergic s ... Read More
A 46-year-old member asked:
Dr. Anlin Xu
Dr. Anlin Xu answered
23 years experience in Allergy and Immunology
Yes: Claritin is a second generation antihistamine which causes much less drowsiness than first generation antihistamine, like benadryl (diphenhydramine). ... Read More
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A 53-year-old member asked:
Dr. Nicholas Nomicos
Specializes in General Practice
Yes, but...: While there is no direct medication interaction, that is a lot of antihistamine. I wouldn't advise the combination and would probably do allergy test ... Read More
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A 45-year-old member asked:
Dr. John Norvell
20 years experience in Allergy and Immunology
No: Benadryl (diphenhydramine) is a short-acting antihistamine and is more likely to make you sleepy when used. Fexofenadine is a second-generation, non- ... Read More
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A 49-year-old member asked:
Dr. David Shulan
40 years experience in Allergy and Immunology
Usually yes, but why: Taking the two together though usually does not offer much in the way of additional benefit for nasal allergies.
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A 55-year-old member asked:
Dr. Brian Bezack
17 years experience in Pediatric Pulmonology
Not advisable : I would not take both at the same time because these medications do the same thing and can have additive effects if used together. They are both antih ... Read More
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A 38-year-old member asked:
Dr. Stuart Kanter
20 years experience in Geriatrics
No: Both are antihistamines and combining them will no provide any greater benefit.
A 49-year-old member asked:
Dr. Stuart Kanter
20 years experience in Geriatrics
Different drug class: Although both are antihistamines, they are different chemicals. Benadryl (diphenhydramine) is sedating. Loratadine is not.
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A 40-year-old female asked:
Dr. Michael Zacharisen
32 years experience in Allergy and Immunology
Not necessary: Both Allegra (fexofenadine) and Claritin (loratadine) are new generation antihistamines. There is no particular advantage to taking both together. O ... Read More
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A 49-year-old member asked:
Dr. William Culviner
29 years experience in ENT and Head and Neck Surgery
Not recommended: Those are both drugs of the same classification , antihistamines. They should not be taken together, one or the other. If you need more help with you ... Read More
A 41-year-old member asked:
Dr. Michael Zacharisen
32 years experience in Allergy and Immunology
Both antihistamines: Allegra (fexofenadine) and zyrtec (cetirizine) are both new generation antihistamines affecting h1 receptor. They are different compounds but essenti ... Read More
A 38-year-old member asked:
Dr. Brian Bezack
17 years experience in Pediatric Pulmonology
You shouldn't: Both medications are in the same class called non-sedating antihistamines and are effective for 24 hours. They should not be taken at the same time.
A 39-year-old member asked:
Dr. Michael Zacharisen
32 years experience in Allergy and Immunology
Yes, but why: Allegra (fexofenadine) and Benadryl (diphenhydramine) are both antihistamines. Allegra doesn't cross into the brain, so no sedation. Benadryl common ... Read More
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A 45-year-old member asked:
Dr. Thomas Klein
40 years experience in Allergy and Immunology
Yes: I would space the two out: Claritin (loratadine) in the am and zyrtec at night. I like Allegra more than claritin (loratadine).

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. Get help now:

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