Question 1

what is the definition or description of: irinotecan allergy?

Accepted Answer

Allergy/side effect: Side effects are known adverse reactions that occur due to the metabolism of the medication or the mechanism of action of the drug that just happens to be undesirable or toxic. Typical allergic reactions (type i hsr) consist of flushing, hives, itching, swelling, respiratory symptoms or GI symptoms. True allergic reactions can  be desensitized by an allergist trained to perform the procedure.

Question 2

what is the definition or description of: camptosar (irinotecan) allergy?

Accepted Answer

Gi symptoms: &gt;10% Diarrhea, nausea, vomiting, anorexia, constipation, flatulence, stomatitis.

Question 3

who should not use irinotecan?

Accepted Answer

Irinotecan: "Irinotecan hydrochloride injection is contraindicated in patients with a known hypersensitivity to the drug or its excipients."  See:  http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2361c88c-124e-4f6c-aef2-c70612f0eb64

Question 4

who should not use irinotecan injections?

Accepted Answer

Irinotecan: "Irinotecan hydrochloride injection is contraindicated in patients with a known hypersensitivity to the drug or its excipients." See:  http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2361c88c-124e-4f6c-aef2-c70612f0eb64

Question 5

do you need a prescription for irinotecan?

Accepted Answer

Irinotecan: Irinotecan is available by prescription.

Question 6

can pregnant women use irinotecan?

Accepted Answer

Irinotecan: Irinotecan is FDA Pregnancy Category D (Positive evidence of risk).

Question 7

can pregnant women use irinotecan injections?

Accepted Answer

Irinotecan: Irinotecan is FDA Pregnancy Category D (Positive evidence of risk).

Question 8

cea is rising 1 point per month while on irinotecan . does this mean not responding to treatment ?

Accepted Answer

CEA and chemo: If the CEA has been used to monitor response to treatment than a rise and a steady rise would mean that cancer is producing the CEA.  It might be a good time to actually go back and plot the values to make sure the rise is real. If so a repeat of scans might be in order

Question 9

what happens if for mcrc, xeloda (capecitabine) n irinotecan has failed ? the person has about 3,4 mets ?

Accepted Answer

Not really: Having failed does not necessarily represent progression of metastasis but possibly no evidence of extensive disease progression.  In such a case if disease is in liver isotope infusion or chemoembolization may help.  If new lung lesions are seen, they may be amenable to resection and if progression has occurred newer immunotherapy approaches such as with Neo 102 can give better than 1 yr. survival .

Question 10

if xeloda (capecitabine) n irinotecan failed does this mean person with mcrc is chemotherapy resistant ?

Accepted Answer

Maybe: The treatment for metastatic colorectal Ca also includes FOLFOX which includes the platinum drugs as part of the combo.  If not yet taken one should consider this protocol.  I usually obtain fresh tumor from bx to  send for chemosensitization.  If these fail, chemo with Erbitux or Avastin (bevacizumab) may prove beneficial.

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Doctor answers about:

Irinotecan allergy

A member asked:

What is the definition or description of: irinotecan allergy?

A member asked:

What is the definition or description of: camptosar (irinotecan) allergy?

A member asked:

Who should not use irinotecan?

A member asked:

Who should not use irinotecan injections?

A member asked:

Do you need a prescription for irinotecan?

A member asked:

Can pregnant women use irinotecan?

A member asked:

Can pregnant women use irinotecan injections?

A member asked:

Cea is rising 1 point per month while on irinotecan . does this mean not responding to treatment ?

A member asked:

What happens if for mcrc, xeloda (capecitabine) n irinotecan has failed ? the person has about 3,4 mets ?

A member asked:

If xeloda (capecitabine) n irinotecan failed does this mean person with mcrc is chemotherapy resistant ?

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