Question 1

what disorders produce low cd4 antigen and high cd8?

Accepted Answer

A classic: Hi. A classic for that profile would be HIV. If you are at risk, I'm sure your doctor has thought of that. Why was the CD4/CD8 profile ordered? Have you had any opportunistic infections? If HIV negative, I suspect your doc may refer you to an infectious disease specialist. Good luck!

Question 2

dr said my blood test is essentially normal was a tcell phenotype with high cd8 normal at 931 normal cd4 cd8 cd45ra naive was high at 735 why does he say normal and does this point to anything concern?

Accepted Answer

: Why did you have this test? CD4/8 testing normally is only done in people with HIV to follow their immune functioning over time. If that's your situation, these are great numbers, showing a strong cellular immune system without serious damage (yet?) from HIV, or that your anti-HIV treatment is effective. There are few other reasons for such testing, but in any case these numbers look great.

Question 3

bcell immunophenotyping shows a decrease in total memory b cells cd27+ driven by the decreases in both marginal zone cd27 m+ d+ and class switch memory b cd27+m-d- tcell phenotype showed high cd8 cd45ra naive also abdomen scan showed 13.1cm spleen?

Accepted Answer

: Since this testing is done to diagnose or classify bone cell cancers and lymphomas &amp; to guide therapy   &amp; for prognosis, you'll have to obtain information from an.oncologist.

Question 4

neg. 4 hiv. h/s ratio  low 0.84. cd4 ratio was low at 30.7. cd8 ratio  high at 36.5. both adsolute were normal cd4 583 cd8 694. should i be concerned?

Accepted Answer

HIV negative: The HIV test is the only one that matters. If you were tested long enough after the last possible exposure (4-8 weeks, depending on the particular test or combination of tests), you don't have it. It was pointless to have the other tests. Nobody without a positive HIV test should be tested for CD4 etc. Your results are fine and don't indicate any health problem. Stop testing.

Question 5

what do very high levels of cd3+ and cd8+ mean?

Accepted Answer

Could be many things: The interpretation of laboratory tests involves comparison with the "normal" ranges in the context of the symptoms that are being experienced by the patient. There is no way to get an answer to your question other than to discuss it with the physician who ordered the tests.

Question 6

what do very high levels of cd3+ and cd8+ in blood mean (in the 2300 range)?

Accepted Answer

It depends: Cd markers tell us what subsets of lymphocytes we have in our blood. Cd3 is found on the surface of all t cells. T cells are involved in directing other immune cells and in killing other cells. Cd8 cells are a subset of cd3 cells, and are commonly called cytotoxic t cells. They can go up in a viral infection, leukemia, etc. You need to know your other subsets, and if any other markers are abnormal.

Question 7

cd4 and cd8 ratio is 4.0 and it says my t cells are elevated. why does that mean?

Accepted Answer

See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the data you provided is not a cause for concern. Why was the test done? Do you have any symptoms? What were the results of other tests? It would be best discussed with the doctor who ordered the test.

Question 8

35yo m hiv neg. cd3, cd4, cd8 mildly depressed, cd19 mildly elevated.fatigue large complaint. possible causes of immune dysfunction listed?

Accepted Answer

Horses, not zebras: You don't have "immune dysfunction."  you have a mild abnormality of a lab test that shouldn't have been drawn in the first place.  Focus on common causes of fatigue, not rare ones.

Question 9

what does a low cd8 mean?

Accepted Answer

It depends: Why were CD8 lymphocytes measured in the first place. If you have a low total number of lymphocytes, then CD8 may be low as part of the lymphocytopenia. CD4 lymphocytopenia is well described, not CD8.

Question 10

what is the definition or description of: cd8?

Accepted Answer

Cluster of different: Cd8(cluster of differentiation8)is a transmembrane glycoprotein that serves as a co-receptor for the tcell receptor(tcr) like the tcr, cd8 binds to a major histocompalibility complex(mhc) molecule, but is specific for the class 1 mhc protein
there are two isoforms of the protein, Alpha and beta, each encoded in a different gene in humans.Both genes are located on chromosome2 in position 2p12.

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Doctor answers about:

High cd8

A member asked:

What disorders produce low cd4 antigen and high cd8?

A member asked:

Dr said my blood test is essentially normal was a tcell phenotype with high cd8 normal at 931 normal cd4 cd8 cd45ra naive was high at 735 why does he say normal and does this point to anything concern?

A member asked:

Bcell immunophenotyping shows a decrease in total memory b cells cd27+ driven by the decreases in both marginal zone cd27 m+ d+ and class switch memory b cd27+m-d- tcell phenotype showed high cd8 cd45ra naive also abdomen scan showed 13.1cm spleen?

A member asked:

Neg. 4 hiv. h/s ratio low 0.84. cd4 ratio was low at 30.7. cd8 ratio high at 36.5. both adsolute were normal cd4 583 cd8 694. should i be concerned?

A member asked:

What do very high levels of cd3+ and cd8+ mean?

A member asked:

What do very high levels of cd3+ and cd8+ in blood mean (in the 2300 range)?

A member asked:

Cd4 and cd8 ratio is 4.0 and it says my t cells are elevated. why does that mean?

A member asked:

35yo m hiv neg. cd3, cd4, cd8 mildly depressed, cd19 mildly elevated.fatigue large complaint. possible causes of immune dysfunction listed?

A member asked:

What does a low cd8 mean?

A member asked:

What is the definition or description of: cd8?

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