Question 1

what is the cytochrome p450 2d6 enzyme system?

Accepted Answer

2D6: Cytochrome 2d6 is one of the p450 monooxygenases- a large and diverse group of enzymes that catalyze the oxidation of organic substances.

Question 2

i recently learned my cytochrome p450 oxidase 2e1 is partially reduced, my gstm1 is absent, and my meh only partially works. what does this mean, how common is it, and how can i improve my detox?

Accepted Answer

Personal genomics: I have a similar condition that i discovered after having whole genome sequencing via the personal genome project.  The 2e1 system is part of a super family of enzyme systems in the liver.  Many medications and most environmental toxins are metabolized thru this pathway. Eh & gstm1 two other major detox pathways if compromised may increase the risk for certain cancers and impair drug metabolism.

Question 3

any way to repair cytochrome p450?since i took fluoroquinolones 8 months ago i feel toxic and no medication that used to work isnt working anymore

Accepted Answer

No: It is unlikely that fluoroquinolone you took. 7 months ago is causing side effects now . See a physician and discuss your complaints in detail. Some blood work nay also be necessary

Question 4

i take thaden & zopiclone. cytochrome p450 inducers & inhibitors are a huge problem and my diet is limited. what can i do to improve drug metabolism?

Accepted Answer

Diet and exercise: Multivits, diet and exercise should be your mainstay. Conult with a registered dietician and nutritional expert.

Question 5

i have metastatic bc. i am very drug-sensitive. i have had a hard time with any drugs given for cancer. can my dr do a cytochrome p450 test to determine how a drug metabolizes? 4 drugs were tried and i have had severe reactions?

Accepted Answer

: Your request is very reasonable, and such metabolic blood studies are readily available.  Some of these surveys will also  reveal potential drug-drug interactions.  One salient issue will involve insurance coverage.  Explore this with your oncologist or internist.

Question 6

femara (letrozole) is metabolized in liver by cytochrome p450 system. astaxanthin says "use cautiously w drugs metabolized by liver's cytochrome p450 enzyme system; does this mean don't use astaxanthin w femara (letrozole)?

Accepted Answer

Not necesarilly but: Virtually all drugs are metabolized by cytochrome p450 enzymes.Astaxanthin can stimulate these, so it could lead to lower blood levels of "certain drugs" according to http://www.Naturalmedicinejournal.Com/article_content.Asp?Article=293. I no of no evidence that Femara (letrozole) is one of the drugs it interacts with. Small amounts of astaxanthin are unlikely to have much effect.Ask the doc who prescribed it.

Question 7

for educational purposes, i look up any meds i take. which cytochrome p450 enzymes metabolize the first-gen antihistamine periactin (cyproheptadine hydrochloride)? or are effected?

Accepted Answer

Cyproheptadine: Aromatic ring hydroxylation ( followed by glucuronide conjugation), and n-demethylation, end heterocyclic ring oxidation were shown to occur in man. The principal metabolite, however, was identified tentatively as a quaternary ammonium. Glucuronide-like conjugate of cyproheptadine.  The exact mechanisms for the glucuronidation are not entirely clear.

Question 8

does cytochrome p450 enzyme have anything to do with liver enzymes (alt, ast)?

Accepted Answer

Yes - both in liver: cytochrome  p 450 is principally in the liver and processes medications protecting the liver from injury

alt and ast are liver enzymes that are elevated in liver injury

Question 9

my muscle biopsy said, "cytochrome oxidase: fibers with total absence of staining." would that be type iv? what doctor needs to review my report?

Accepted Answer

Complex IV: Cytochrome C oxidase deficiency is a rare disorder which is associated with Complex IV in the mitochondria.  Patients with this should see a neuromuscular specialist (typically a neurologist) who can help assess the clinical approach.

Question 10

whats the half life of testosterone cyp?

Accepted Answer

Testosterone Cyp....: This injectable form of long acting testosterone can act with varying effectiveness based upon dose and frequency of administration.  But, a good and common treatment schedule would have you take this shot every ten to fourteen days.

If your medical provider is easily accessed they can provide you good guidance for your specific situation.

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Doctor answers about:

Cytochrome p450 2c9 and vkorc1

A member asked:

What is the cytochrome p450 2d6 enzyme system?

A member asked:

I recently learned my cytochrome p450 oxidase 2e1 is partially reduced, my gstm1 is absent, and my meh only partially works. what does this mean, how common is it, and how can i improve my detox?

A member asked:

Any way to repair cytochrome p450?since i took fluoroquinolones 8 months ago i feel toxic and no medication that used to work isnt working anymore

A member asked:

I take thaden & zopiclone. cytochrome p450 inducers & inhibitors are a huge problem and my diet is limited. what can i do to improve drug metabolism?

A member asked:

I have metastatic bc. i am very drug-sensitive. i have had a hard time with any drugs given for cancer. can my dr do a cytochrome p450 test to determine how a drug metabolizes? 4 drugs were tried and i have had severe reactions?

A member asked:

Femara (letrozole) is metabolized in liver by cytochrome p450 system. astaxanthin says "use cautiously w drugs metabolized by liver's cytochrome p450 enzyme system; does this mean don't use astaxanthin w femara (letrozole)?

A member asked:

For educational purposes, i look up any meds i take. which cytochrome p450 enzymes metabolize the first-gen antihistamine periactin (cyproheptadine hydrochloride)? or are effected?

A member asked:

Does cytochrome p450 enzyme have anything to do with liver enzymes (alt, ast)?

A member asked:

My muscle biopsy said, "cytochrome oxidase: fibers with total absence of staining." would that be type iv? what doctor needs to review my report?

A member asked:

Whats the half life of testosterone cyp?

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