Question 1

can you tell me how chloroquine kill the malaria parasite?

Accepted Answer

Antimalarial drugs: It's a little bit technical - but basically the medicine acts as a 'poison' for the malaria parasite. Plasmodium species have to digest hemoglobin (inside the red blood cell) to survive - but the heme molecule can be toxic when released. Therefore, the parasite tries to sequester that away. Chloroquine interferes with that step - thus leading to a slow poisoning of the parasite. Hope that helps.

Question 2

chloroquine suggested for sars-cov-2? why would a malaria drug to kill a plasmodium also work to destroy a virus?

Accepted Answer

No evidence: There isn't current evidence that Chloroquine kills SARS-CoV-2. The FDA cautioned against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems.

Question 3

i am an african and aa blood type.i have just treated malaria with my usual lonart ds drug three days ago and suprisingly the aches and pain symptoms still persist.my body also itch in a manner akin to the days of chloroquine drugs.what could be wrong?

Accepted Answer

Several possibities: You may be reacting to side-effects of the medication, the parasite may be resistant to the medication you are receiving, you may have an illness either along with or in place of the diagnosis of malaria.  See your doctor.

Question 4

how does the antimalarial chloroquine work? does it passively diffuse into red blood cells to thwart the malaria parasite or does it enter the red blood cells by an active transport process?

Accepted Answer

Chloroquine: Chloroquine concentrates up to several 1000-fold in the food vacuole of the parasite. Possible mechanisms for this selective accumulation of Chloroquine in the food vacuole are: 1) protonation and ion trapping of the Chloroquine due to the low ph of the food vacuole; 2) active uptake of Chloroquine by a parasite transporter(s); and/or 3) binding of Chloroquine to a specific receptor in the food va.

Question 5

am breast feediing 4 moths child, can i safely use malarone (atovaquone and proguanil)  or chloroquin for malaria.

Accepted Answer

Antimalarial/nursing: Both can cross over into breast milk, but not in sufficient quatities to cause harm to your infant. To be safe, stop breast feeding and use formula if available. See your provider for advice, since dosage amounts of antimalarials can vary for other reasons, and may be harmful if nursing is continued over time.

Question 6

what are risks of drug resistant malaria?

Accepted Answer

Malaria: Most drug-resistant malaria is caused by the falciparum species which is the one causing most deaths for malaria.  Inadequate prevention or poor treatment can result in death.

Question 7

how is it possible that sickle-cell disease are resistant to malaria, meaning they can't get malaria. how is this possible?

Accepted Answer

Unstable red cells: Malaria infects red blood cells.  In order to propagate, malaria needs the red cells to survive being infected, so that the infection can persist, infecting other red blood cells.  Sickle red cells are not stable at all, which does not allow the infection to last in those patients.

Question 8

how would mosquitos carrying the malaria parasite become resistant to some of the drugs used?

Accepted Answer

It is part of the: Evolutionary concept of survival of the fittest.

Question 9

i'm wondering why are carriers for sickle cell anemia resistant to malaria?

Accepted Answer

Sickle and malaria: Patients with sickle cell disease are protected against  severe and complicated malaria infection- by 2 mechanism: -1.  Cells infected with malaria parasites had accelerated sickling compared with non-infected cells- and as the result the cell would be destroyed/ promoting removal of infected cells from the circulation
`2.Impaired parasite growth due to reduce o2 content in sickle cell.

Question 10

why are people who are heterozygous for sickle cell anemia more resistant to malaria?

Accepted Answer

Malaria: In a person who has sickle-cell trait – the red blood cells are destroyed prematurely before the Plamodium can reproduce.  Sickle Cell Trait can provide a protective advantage against P. Falciparum. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16 months of life, before the onset of clinical immunity in areas &gt;

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Doctor answers about:

Chloroquine resistant malaria map

A member asked:

Can you tell me how chloroquine kill the malaria parasite?

A member asked:

Chloroquine suggested for sars-cov-2? why would a malaria drug to kill a plasmodium also work to destroy a virus?

A member asked:

I am an african and aa blood type.i have just treated malaria with my usual lonart ds drug three days ago and suprisingly the aches and pain symptoms still persist.my body also itch in a manner akin to the days of chloroquine drugs.what could be wrong?

A member asked:

How does the antimalarial chloroquine work? does it passively diffuse into red blood cells to thwart the malaria parasite or does it enter the red blood cells by an active transport process?

A member asked:

Am breast feediing 4 moths child, can i safely use malarone (atovaquone and proguanil) or chloroquin for malaria.

A member asked:

What are risks of drug resistant malaria?

A member asked:

How is it possible that sickle-cell disease are resistant to malaria, meaning they can't get malaria. how is this possible?

A member asked:

How would mosquitos carrying the malaria parasite become resistant to some of the drugs used?

A member asked:

I'm wondering why are carriers for sickle cell anemia resistant to malaria?

A member asked:

Why are people who are heterozygous for sickle cell anemia more resistant to malaria?

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