8 doctors weighed in:

What are radio protectants, and can they decrease my side effects from radiation therapy?

8 doctors weighed in
Dr. R. Scott Anderson
Radiation Oncology
3 doctors agree

In brief: See below

Radioprotectants are really only useful if they offer differential radioprotection to normal tissues and not tumor cells.
That's really the problem. A general radioprotectant would benefit the cancer cells as much as normal cells thus you haven't changed the therapeutic ratio.

In brief: See below

Radioprotectants are really only useful if they offer differential radioprotection to normal tissues and not tumor cells.
That's really the problem. A general radioprotectant would benefit the cancer cells as much as normal cells thus you haven't changed the therapeutic ratio.
Dr. R. Scott Anderson
Dr. R. Scott Anderson
Thank
Dr. Bahman Daneshfar
Radiation Oncology
2 doctors agree

In brief: Yes

Amifostine protects good tissue during radiation in certain cases such as head and neck cancers.
It has not been shown to also protect the cancer which is a good thing but there is the concern of using protectants while you are trying to kill cancer. But we use radiosensitzers more often than protectants because we want to have a better effect in killing the cancer.

In brief: Yes

Amifostine protects good tissue during radiation in certain cases such as head and neck cancers.
It has not been shown to also protect the cancer which is a good thing but there is the concern of using protectants while you are trying to kill cancer. But we use radiosensitzers more often than protectants because we want to have a better effect in killing the cancer.
Dr. Bahman Daneshfar
Dr. Bahman Daneshfar
Thank
Dr. Andrew Turrisi
Radiation Oncology

In brief: WR-2721

Was developed by the army for b-52 pilots.
It didn't cross to protect the brain, and turns out to be too toxic for most clinical use (hypotension and vomiting). It was differentially, and time-related taken up by normal tissues more than tumors. See amifostine, or ethiofos. As a product, it is hard to use and quite expensive.

In brief: WR-2721

Was developed by the army for b-52 pilots.
It didn't cross to protect the brain, and turns out to be too toxic for most clinical use (hypotension and vomiting). It was differentially, and time-related taken up by normal tissues more than tumors. See amifostine, or ethiofos. As a product, it is hard to use and quite expensive.
Dr. Andrew Turrisi
Dr. Andrew Turrisi
Thank
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