If your taking antibiotics and on the depo-provera shot will the antibiotics affect the shot?

No: Antibiotics do not affect depoprovera.

Depot: The best answer i can give you to your question about depot Provera (medroxyprogesterone) is that no it will not be affected by antibiotics. Taking biotics usually affects the absorption of the birth control from the gastrointestinal tract. Since this method of birth control bypasses the gut it should have minimal or no impact.