Been on depo-provera for 4 yrs. i have been spotting for 3 weeks. next depo-provera shot due in 2 weeks. should i be concerned about the spotting?

See you MD: There are many different reasons for having spotting before a period including pregnancy! your md will ask about your history. Age , medical conditions like thyroid disease and diabetes, life stress, strenuous exercise, and eating disorders are a few things which can affect the menses. A blood pregnancy test may be considered.