Endothelial damage: Endothelial damage to blood vessels usally has multiple causes. Research indicates that the damage occurs when endothelial cells are in an "inflammatory" state, yet this state is not due to vitamin or anti-oxidant deficiencies alone. Other metabolic factors such as LDL levels and LDL subtypes, diabetes, mechanical sheer stress from elevated blood pressure and genetic factors all play a role.
Answered 5/30/2016
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