Is it possible to get pregnant if you only got the depo shot twice and the second timeyou had sex days after the shot?

No, but...: Anything is possible in real life. The Depo shot works very well (works right away) if a woman is on her second shot and did not get the shot too late. However, life can surprise you sometimes. A woman who thinks she might be pregnant can do a home urine pregnancy test. They are very accurate 3 weeks after sex, are inexpensive, and are sold in stores everywhere.