Hi i have been on depo coming up 6 years now.. i am 8 days late for my next shot.... my breasts are more fuller & tender...normal symptoms?

Take a test: Depoprovera should still be effective for a two week window after the there months. If you think you might be pregnant check then check a home pregnancy test. They are cheap, reliable and available at any pharmacy. Consider switching to another method. Long term depo use is associated with bone loss leading to osteoporosis later in life.

Depo injection : Breast fullness and tenderness can be a sign of pregnancy, please get pregnancy test done .