DNA breakage: At the end of the day, it's really the structure and functioning of sperm dna that has to be "normal" for an egg to fertilize in ivf. If the sperm dna is heavily fragmented, pregnancy may not occur, or if it does it can miscarry. Frag occurs for many reasons like smoking or chemical exposure or varicocele. I try to either fix these or certainly consider icsi.
Answered 11/4/2014
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