A 21-year-old member asked:
How are the porphyrias inherited? can my children inherit porphyria from me?
2 doctor answers • 6 doctors weighed in
Psychiatry 39 years experience
It is possible: It is autosomal dominant. In addition there are 200 different mutations. The porphobilinogen deaminase gene is responsible - not providing enough to breakdown heme.
1-5 cases per 100, 000 people in the USA.
6.1k viewsReviewed >2 years ago
Dr. Anthony LaBarberaanswered
Pediatrics 28 years experience
See below: Case of porphyria vary in their inheritance pattern. Some are autosomal dominate and only require one gene to be inherited. So the child would have a fifty percent chance. Others are autosomal recessive and require two genes, one form each parent. The child would have a twenty five percent chance.
5.5k viewsAnswered >2 years ago
Last updated Jul 28, 2018
Connect with a U.S. board-certified doctor by text or video anytime, anywhere.
24/7 visits - just $39!
50% off with $15/month membership
Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.