A member asked:

How are the porphyrias inherited? can my children inherit porphyria from me?

6 doctors weighed in across 2 answers
Dr. K. Olson answered

Specializes in Psychiatry

It is possible: It is autosomal dominant. In addition there are 200 different mutations. The porphobilinogen deaminase gene is responsible - not providing enough to breakdown heme. 1-5 cases per 100, 000 people in the USA.

Answered 7/28/2018

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See below: Case of porphyria vary in their inheritance pattern. Some are autosomal dominate and only require one gene to be inherited. So the child would have a fifty percent chance. Others are autosomal recessive and require two genes, one form each parent. The child would have a twenty five percent chance.

Answered 11/12/2012

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