No: Both are antihistamines, and the Claritin is very long acting (12-24 hours), so the Benadryl (diphenhydramine) would be a double dose of similar drugs and likely cause increased side effects--sleepiness, irritability, dry mouth or behavior change. You should wait 12-24 hours to give the benadryl (diphenhydramine).
Answered 6/24/2014
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