Omeprazole administration at day or night?

Omeprazole should be taken 30-60 minutes before a meal and best if it is before breakfast. If someone is taking omeprazole twice daily, it should be taken before breakfast and before dinner.

There seems to be a difference in efficacy between morning and evening dosage of omeperazole depending on whether there is nocturnal reflux , with a preference for evening dosage , and reflux induced by physical activity, which is better helped by morning dosage .Testing for this by doing a 24hr oesophageal ph measurement might help to get some patients the maximum benefit from the medication