How long does c-diff last?

Depends: In most cases, c diff is treated with 2 weeks of antibiotics. This is effective around 85% of the time, but 15% can "relapse" after their antibiotics. This requires more antibiotics. After that, an even higher % will have a 2nd relapse. Treatment is with even more antibiotics. And so on. Some patients have had relapsing diff for years! we can often cure them with a stool transplant.