Is it ok to take four 25mg prednisone at one time direction say 2 tablet twice day?

As per the order: It is always important to take medication as prescribed by the physician since he has his own reason why he did so . Prednisone can be prescribed in variety of ways including once a day . However , I have to reiterate that you need to follow your provider's instruction and ask for any questions because he /she is in the best position to understand them. Good luck.

In theory, yes.: In general, it doesn't matter whether you take Prednisone all at once or in divided doses. However, 100 mg is a fairly high dose and side effects are going to be more likely. The answer right way to take it may differ depending on the illness being treated, the size of the patient, or other medical issues involved. I recommend checking with your doctor to be sure.