How long does imodium (loperamide) multi symptom relief work in your system for?

Depends: In adults, Imodium (loperamide) can be taken up to four times a day, for two days, for the managment of diarrhea. It will likely remain in your system for at least a half-day but the effects of this drug are not the same in all people. Some people require taking this medication after each loose bowel movement (up to four times a day), while others may not need such a high dose.