Can amoxicillan mixed with blood pressure meds affect you sexually?

Maybe other reason: Typically wouldn't think of Amoxicillin by itself as a libido decreaser. Some blood pressure medications by themselves can cause libido problems. Also, the illness for which you are taking Amoxicillin is probably more likely the cause. Ill people's sex drive is decreased. If your sex drive was fine before the illness and penicillin, it should normalize afterwards. If not, check with your doc.