What leads to a leg amputation?

Serious problems: Serious conditions such as severe infections or very low blood flow to the leg can lead to amputation. Sometimes a serious infection can get into the bone causing osteomyelityis, and sometimes antibiotics do not always work. Low blood flow risks are increased in cigarette smokers and diabetics. Ischemic or infected tissues can sometimes cause serious troubles, negatively affecting other organs.

Gangrene: In most instances the people that have an amputation of a leg are those that have overwelming gangrene or overwhelming infection leading to gangrene.