How to defeat acne?

It's not simple: There is no simple answer to this question. It depends on the type of acne, their extent (face, shoulders, neck, chest, etc.), what you've already tried. I would suggest seeing a doc in your area that will do exam and monitor your treatment response. A # of topical treatments and oral ones are available and can be used with good response, but let your doc decide which one is good for you.