Can i take chantix with all my other medication ?

No drug interactions: There are no drug interactions but you must be aware of the fact that Chantix can cause depression, particularly in people who are depression prone.I don't know exactly why you are taking zoloft, (sertraline) but if you are taking it for depression then be extra careful. If you have even one day of significant depression i would recommend that you stop the Chantix immediately and call your treating physician.