What leads to antiphospholipid syndrome?

It is autoimmune: Antiphospholipid syndrome(aps) is an autoimmune condition which can be its own entity or associated with other connective tissue diseases such as lupus. A diagnosis requires thorough evaluation by a rheumatologist. Typically, we don't make a diagnosis after one test result. The general rule of thumb is to repeat the test 3 months after the first one to confirm. There is more than one test.

It can be genetic: One can inherit this syndrome, or it may arise without any apparent history or cause. It is associated with multiple medical problems, including recurrent pregnancy loss.