Who is most likely to develop biliary cirrhosis?

PBC--who gets it: 90% of pbc patients are female. Age ranges 20-80, but typically patients are 40-60. The disease is world-wide, & affects asians, caucasians, jews, african. Family clustering is common in sisters, twins, daughters, mothers. While environmental factors can't be ignored, a strong immunogenetic background for pbc that runs in families is suggested. Early sxs: fatigue, itching before jaundice, RUQ pain.

Alcoholics: Alcohol is the leading cause of cirrhosis or liver failure. Hepatitis or liver infection with hepatitis c is probably 2nd. There is also an increasing incidence of liver failure from having a fatty liver due to obesity. There are numerous other rarer causes.