Do acne oral medications cause dry and sensitive skin?

Isotretinoin does: Isotretinoin, better known as accutane, frequently causes dry, sensitive skin. It is important to moisturize your skin and wear sun protection while using this medication. Oral antibiotics may make you more sensitive to the sun but should not cause dryness.

Not yours: Neither minocycline nor spironolactone cause dry skin. Isotrinoin [Accutane] causes very dry skin.