I have taken macrobid, bactrim, (sulfamethoxazole and trimethoprim) nitrofum and other meds that have failed with my chronic uti. should i be taking something else or could i be misdiagnosed?

Culture: You need a culture...That can identify the specific bug, and what it is sensitive to.

Recurrent UTI's: Has a urine culture been done to determine what bacteria are causing the infections? Culture is accompanied by sensitivity testing to decide which antibiotic works best against the bacteria? Are you diabetic? Do you drink a lot of pop? You may have interstitial cystitis, which affects the bladder lining. See a urologist for a thorough work-up and treatment.

Resistant bug: It is utmost important to get urine culture and identify the causative organism(bug) before starting another antibiotics which will allow choosing most effective medicine. Recurrent cystitis, common malady in sexually active women, generally requires short course of effective antibiotics. Voiding urine and taking antiuriseptic, e.g., uroquid, after sexual activity would be of help in prevention.

Source control?: If source control isn't achieved, then no abx will help. This could range from an infected renal stone and anatomical issues leading to retention of urine, to physiologic problem (such as overactive bladder). Otherwise, an alternative diagnosis that mimics a UTI exists. Some situations demand specialists expertise - in some cases, an infectious diseases consult may be of benefit.