A member asked:

How common is the variant hook effect?

A doctor has provided 1 answer

Unclear question: Are you referring to the "hook" effect in immune assays? If yes, the frequency varies with the clinical situation. A common time for the hook effect is in secondary syphilis. Any test in which there is very high differential in the amount of antigen and antibody may result in hook effect; also called prozone phenomenon.

Answered 6/12/2013

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