Could you tell me what are long term affects of lack of oxygen to legs in emphysema?

Oxygen delivery: Lack of oxygen to any part of the body from any cause may cause ischemia. This causes the cells to do their work via alternate pathways. This causes Lactic Acid buildup pain and eventually cell death. Claudication is a term you may have heard when there is poor circulation to the legs causing pain. The poor circulation reduces the amount of oxygen delivered.