What are possible causes of restless leg syndrome?

Often not clear: Some patients have low iron levels and those that do can have symptom relief when iron is supplemented. There is a genetic component to restless legs syndrome as it often runs in families. Many patients don't have an underlying cause.

Many: Genetics, alcohol and caffeine, changes in exercise patterns, certain meds, iron deficiency, kidney problems, nerve damage can all cause or worsen restless legs syndrome.