Are there any serious side effects to smoking weed for the first time?

Potentially: Although cannabis is well tolerated by many, it can have disatrous impacts on others. Possible effects of marijuana: anxiety, depression, fear, panic , delusions, hallucinations, losing touch with reality, inattentiveness, short-term memory problems, disturbances of thought processes. Fatigue, poor concentration, slowed reaction times & slowed problem solving.