Can i take valerian root while weaning off of cymbalta (duloxetine)?

Not a good plan: Cymbalta (duloxetine) and valerian root can both be toxic to your liver, so combining them would not be a good idea. Also some sources indicate potential cytochrome interactions between these 2, so that there may be changes in how your body clears these substances when used together. If tapering your Cymbalta (duloxetine) and having difficulty, please speak with your doctor.