Can continuous use of phenobarbiturates have an extensive affect on memory?

It is possible.: Can you stop the phenobarbs? Are you taking for sleep? Try melatonin. No side effects.

Yes: Yes. Chronic use of barbiturates can affect memory and thinking abilities. It can also result in behavioral and learning problems, particularly in children. Most of this is reversible once the medications have been stopped. In some cases, some of the side effects may continue for some time after the medication has been stopped because these drugs take a few weeks-months to be totally cleared.