What are the causes of the pain when you have a ruptured annulus fibrosis?

Chemicals: From the inside of the disk, called nucleus pulposus. They include cgrp, phospholipase a2 and others which inflame nerve roots when they leak out.

Pain generators: There are multiple causes of pain from a herniated disc (requiring tearing of the annuls fibrosis and often with rupture of the nucleus material through the tearing): Vertebral bone endplate pain (basivertebral nerve), Annular surface nerves (Sharpey's fibers), irritation of the dura mater (vagus nerve), and/or irritation of local nerve roots chemically. There are also mechanical factors .