No. Drugs are VERY similar - valcyclovir is better absorbed than acyclovir and therefore is more often prescribed. In general, either drug is only effective if given within the first 2-3 days of onset. After that, is not all that helpful (even though it is often given). Make sure you get the zoster vaccine (Shingrix) after the rash has resolved.
Answered 4/15/2021
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