A member asked:

I was given my first depo provera injection at the same time as macrobid for uti. will the macrobid cancel out my depo? period was 2 weeks ago, how long will a backup method be needed?

A doctor has provided 1 answer
Dr. Hunter Handsfield answered

Specializes in Infectious Disease

First, too much often is made about possible antibiotic interference with hormonal contraceptions. This is really, really rare with any antibiotic. And for sure never a problem with nitrofurantoin (Macrobid). It concentrates in urine, with almost undetectable blood levels. It cannot interfere with contraception. Don't worry about it.

Answered 3/7/2021

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