TX
A 25-year-old male asked:
I took 10 mg loratadine (non drowsy 24 hr claritin) 8 hours ago for my allergies. it didnt work and im trying to go to bed so i was wondering if it was safe to take 25 mg diphenhydramine hcl (benadryl) since it does make you drowsy?
2 doctor answers • 3 doctors weighed in
Dr. Edward Kuhnleyanswered
Child Psychiatry 46 years experience
Likely safe: Interaction: Diphenhydramine will increase the level or effect of loratadine by affecting hepatic enzyme CYP2D6 metabolism. It is considered Minor with Significance Unknown. Best regards for good health.
43 viewsReviewed Sep 20, 2020
Dr. James Fergusonanswered
Pediatrics 47 years experience
Expected pattern: Loratadine is one of several non-drowsy antihistamines that take up to a day to achieve a blood level in your system to reach peak effect. Daily use maintains that level. Diphenhydramine works differently achieving peak effect in an hour or so but leaving the body sooner. I see no reason not to use both as their side effect profile does not overlap.The drowsiness would be the same clinically.
43 viewsAnswered Sep 19, 2020
Last updated Sep 20, 2020
People also asked
Connect with a U.S. board-certified doctor by text or video anytime, anywhere.
24/7 visits - just $39!
50% off with $15/month membership
Disclaimer:
Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.