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A member asked:
What makes stimulating the substantia nigra cause depression?
A doctor has provided 1 answer
Dopamine: Stimulation (presumptively by amphetamines) causes a release of dopamine. If this is "supraphysiological" - i.e., more than the body would normally account for - you can end up with a Dopamine deficit. This is the same think as Cocaine addicts have after a run on cocaine, or crank or meth addicts have after a run. The good news is that the body can and will build it back up if allowed to.
Answered 10/24/2017
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