Drug interactions: Alka-Seltzer Plus Cold contains acetaminophen, chlorpheniramine & phenylephrine. Per Drugs.Com drug interaction checker -when chlorpheniramine is mixed with alcohol it could lead to side effects like dizziness, drowsiness, confusion, or difficulty concentrating. In some situations, if there is an unhealthy liver - using acetaminophen with alcohol could contribute to more liver issues.
Answered 4/19/2019
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