Is trazadone safe to take for sleeping while on prozac?

No: Trazodone shares some of the effects of prozac and,thus, there is a danger of provoking the dangerous serotonin syndrome. Your pharmacist can also be helpful in answering questions about your medications.

Yes, Relatively: As others have already noted there is an increased potential for side effects due to the similar action of Prozac and Trazodone. However, it is common to use Trazodone with medicines such as Prozac to try help with sleep, and at low doses the risk is relatively small. However, since there is slight risk, it is important to be caution with the Trazodone dose and stay in contact with your provider.