A member asked:

What is the definition or description of: anal cancer?

A doctor has provided 1 answer

Squamous lesion: The anal canal lesion is squamous in origin. The dentate line marks the upper junction between squamous and mucosal epithelium in the anal canal. ... Tumours near the anal margin spread to the inguinal lymph nodes; those higher in the anal canal spread to the pelvis The Anal Cancer Trial (ACT-1) demonstrated the superiority of using chemoradiation with 5-FU and mitomycin C (MMC).

Answered 6/12/2017

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