What's the success rate for podofilox? does it target the cosmetic effects or the actual hpv virus?

Around 70-80%: Aside from surgery or cautery, all treatments are around 70-80% effective: podofilox, sinecatechins, freezing, trichloroacetic acid, imiquimod. For any of these, switch to another if the first isn't very effective. Combination treatment often is best, e.g. freezing plus podofilox. None target HPV itself, but wart removal reduces HPV load and may speed clearance by the immune system.