HealthTap Online Primary Care Doctors Accepting New Patients
Book a video visit
HealthTap
Telehealth
A member asked:

Can you take two oxycodone 5-325 and liquid benadryl (diphenhydramine) together?

A doctor has provided 1 answer
Dr. Al Hegab answered

Specializes in Allergy and Immunology

No: you don't want to do that, more-over monitor your oxycodone dosage carefully. Combining both drugs or overdosing oxycodone can lead to CNS depression and untoward side effects as respiratory depression. If you are experiencing itching or other symtoms that can be a side effect of drug use, please see your doctor, best wishes

Answered 8/28/2016

1k views

Thank

Related Questions

A member asked:

Do you think I should take pill or liquid form of Benadryl (diphenhydramine) for my bug bite / hives?

A doctor has provided 1 answer

A member asked:

How many Benadryl (diphenhydramine) allergy liquid gels does an adult take?

A doctor has provided 1 answer

A member asked:

How long does it take for liquid Benadryl (diphenhydramine) to wear off?

A doctor has provided 1 answer

A member asked:

Is it safe to take a sleep aid, liquid diphenhydramine HCL, while using caladryl?

A doctor has provided 1 answer

A member asked:

After taking a liquid prescription of benadryl, (diphenhydramine) I feel like someone else is controlling my thoughts. I have stop taking it, but I still feel weird.

A doctor has provided 1 answer

Sponsored Content
HealthTap Medical Group does not endorse products or services. Sponsored content revenues support our mission to make health information free and accessible to all.Learn more

People also searched for:

Mixing diphenhydramine HCL (50mg) with oxycodone (30mg)? Due to an accident, chronic, severe, pain does not let me sleep.......
Can i take benadryl 10 hours after taking a 5 mg oxycodone?
Is it ok to take some liquid benadryl (diphenhydramine) now if I took a .25 xanax at 6pm?
How many liquid-gel Benadryl (diphenhydramine) tablets do I take for an allergic reaction?
How much liquid children's Benadryl (diphenhydramine) can an adult take safely?

Telemedicine

Primary Care
Manage Your Conditions
Women's Health
Children's Health
Men's Health
Senior Health
Wellness, Prevention & Lifestyle
Sexual Health
Mental & Behavioral Health
Travel Medicine
Urgent Care
Ask your question
Didn't find what you're looking for?

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more.

Ask your question

More of what we treat

Allergies
Antibiotics
Asthma
High Blood Pressure
Prescriptions
Type 2 Diabetes
Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.
HealthTap
HIPAA logo
HIPAASecure
Soc 2 Type 2 logo
SOC 2 Type 2Certified
JCAHO Accredited
JCAHOAccredited
Member App

Download HealthTap

Video visit and message your doctor

Member App QR Code
Play Store Member LinkApp Store Member Link

Questions?

+1 (888) 828-0841support@healthtap.com
LinkedInTwitter
HomeTermsPrivacyCookiesDMCAHealth TopicsDoctors DirectoryDoctor Q&A by Specialty
Copyright 2026 HealthTap, Inc.