Not specifically: Phenothiazines (the class of drug Promethazine belongs to) does not really have the potential to have physical dependency and a true withdrawal syndrome, but many people who are on this class of agents as well as antidepressants can have a "discontinuation" syndrome, with anxiety, irritability and sometimes "electric shock" sensations after stopping it suddenly. If that happens, taper it slowly.
Answered 4/18/2016
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