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A member asked:
Is high blood calcium caused by metestatic breast cancer reversable?
4 doctors weighed in across 2 answers
Can be treated: Hypercalcemia of malignancy can be treated. Parathyroid hormone usually meticulously controls serum calcium. Breast cancer cells act through several mechanisms to increase serum calcium through breakdown of bone, etc. Treatment focuses on IV hydration to enable the kidneys to remove excess Ca2+ and medicines to stop bone breakdown and normalize calcium, or dialysis. I hope your treatment goes well
Answered 3/30/2020
1.4k views
Yes: Osteolysis and hypercalcemia not uncommon in metastatic breast Ca to bone. It is primarily mediated by osteoclast not a direct effect of tumor cells but by factors that stimulate osteoclast production and action. Breast Ca cells in bone also express parathyroid-related protein (PTHrP). Locally produced PTHrP causes osteolysis that can be ameliorated by administration of anti-PTH mAbs and chemo
Answered 1/4/2019
1.4k views
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