Overtime, can percocet 7.5/325 4 times daily begin to make you tired, even when it didn't prior to that?

Pain resolution: If your pain problem is receding somewhat, you would expect to find that you are feeling more fatigue than usual. Taking narcotics for chronic pain can be effective but is also problematic in many instances. The best strategy for you as an individual would be to slowly wean yourself off of the narcotic completely except flares. Also routinely take only enough to keep pain to manageable level.