Med Side Effect: Everyone reacts differently to certain medications. The most common side effect of Benadryl (diphenhydramine) is usually sedation but some people find it causes a paradoxical effect. The symptoms you describe do not sound like an allergist reaction. If you require an antihistamine try a non-seading antihistamine like Zyrtec, Allegra, or Claritin and see if you tolerated these better.
Answered 10/17/2017
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