Is stepping in dog urine barefoot hazardous to my health?

Unlikely: Unlikely but it is possible to contract leptospirosis if an immunocompromised person comes in contact with urine from a dog infected with leptospira, a bacterial spirochete. In humans, it usually causes mild flu-like symptoms but can result in high fever, severe headache, hepatitis, abdominal pain, diarrhea, or rash.

Here are some ...: The higher personal unique immune defense ability one has, the less likelihood to contract and develop illnesses at contacting infectious agents like virus, bacteria, etc. We rely on the natural barrier - skin, mucosa, internal health status, and timely vaccination to fend off the invading agents So, for the average healthy, the odd to get disease from step on canine urine is extreme low.